20260420_5AM_10MG.png
20260420_5AM_10MG.png

5-Amino-1MQ

$71.99

Full Name: 5-Amino-1-methylquinolinium

CAS Number: 42816-67-1

Molecular Formula: C₁₀H₁₁N₂O⁺

Molecular Weight: 175.21 g/mol

Appearance: White to off-white powder Solubility: Water-soluble

Storage: -20°C, desiccated, protected from light

Full Name: 5-Amino-1-methylquinolinium

CAS Number: 42816-67-1

Molecular Formula: C₁₀H₁₁N₂O⁺

Molecular Weight: 175.21 g/mol

Appearance: White to off-white powder Solubility: Water-soluble

Storage: -20°C, desiccated, protected from light

Research Context

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the methylation and clearance of nicotinamide. NNMT has emerged as a research target in metabolic studies following the observation that its expression varies significantly across tissue types and metabolic states.

Research interest focuses on NNMT enzymology, NAD+ salvage pathway modulation, and the broader question of how nicotinamide metabolism intersects with cellular energy homeostasis. As a selective NNMT inhibitor, 5-Amino-1MQ provides researchers with a tool compound for studying the consequences of NNMT blockade on intracellular NAD+ dynamics.

Key References

  1. Neelakantan H, et al. (2018). "Selective and membrane-permeable small molecule inhibitors of NNMT." Biochem J. 475(4):827-846. PMID: 29437995

  2. Kraus D, et al. (2014). "NNMT knockdown or inhibition reduces adiposity and enhances energy expenditure." Nature. 508(7495):258-262. PMID: 24717514