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CJC-1295 (No DAC)

$70.00

Full Name: CJC-1295 without Drug Affinity Complex (Modified GRF 1-29)

Also Known As: Mod GRF 1-29, Tetrasubstituted GRF(1-29)

CAS Number: 863288-34-0

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂

Molecular Weight: 3,367.97 g/mol

Appearance: White lyophilized powder

Solubility: Water-soluble

Storage: -20°C, desiccated, protected from light

Full Name: CJC-1295 without Drug Affinity Complex (Modified GRF 1-29)

Also Known As: Mod GRF 1-29, Tetrasubstituted GRF(1-29)

CAS Number: 863288-34-0

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂

Molecular Weight: 3,367.97 g/mol

Appearance: White lyophilized powder

Solubility: Water-soluble

Storage: -20°C, desiccated, protected from light

Research Context

CJC-1295 without DAC (also called Modified GRF 1-29) is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids with four substitutions designed to increase receptor binding and enzymatic stability. It was developed to overcome the rapid degradation of native GHRH in circulation.

Research interest centers on GHRH receptor pharmacology, peptide stability engineering, and the structure-activity relationships involved in extending peptide half-life through amino acid substitution. The four substitutions (positions 2, 8, 15, and 27) each address a specific vulnerability to enzymatic cleavage, making this compound a teaching case in rational peptide design.

Key References

  1. Teichman SL, et al. (2006). "Prolonged stimulation of growth hormone release by CJC-1295." J Clin Endocrinol Metab. 91(3):799-805. PMID: 16352683

  2. Alba M, et al. (2006). "Once-daily administration of CJC-1295." J Clin Endocrinol Metab. 91(5):1726-1733. PMID: 16478822

  3. Ionescu M, Bhatt DL. (2004). "Structure-activity relationships of growth hormone releasing factor analogs." Ann Endocrinol. 65(2):125-130.