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20260420_Semaglutide_20MG.png
20260420_Semaglutide_10MG.png
20260420_Semaglutide_20MG.png

Semaglutide

from $105.00

Full Name: Semaglutide

CAS Number: 910463-68-2

Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight: 4,113.58 g/mol

Appearance: White lyophilized powder

Solubility: Water-soluble (pH-dependent)

Storage: -20°C, desiccated, protected from light

Size:

Full Name: Semaglutide

CAS Number: 910463-68-2

Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight: 4,113.58 g/mol

Appearance: White lyophilized powder

Solubility: Water-soluble (pH-dependent)

Storage: -20°C, desiccated, protected from light

Research Context

Semaglutide is a synthetic GLP-1 receptor agonist developed by Novo Nordisk, featuring an Aib substitution at position 8 and a C-18 fatty diacid chain conjugated via a linker at position 26. These modifications extend its half-life to approximately 7 days — a significant achievement in peptide engineering that makes it a key teaching compound for researchers studying albumin-binding strategies and peptide half-life extension.

The published literature exceeds 5,000 PubMed-indexed articles, making semaglutide one of the most extensively studied peptides in the current literature. Research interest spans GLP-1 receptor pharmacology, incretin signaling, structure-activity relationships, fatty acid conjugation chemistry, and analytical method development for long-acting peptide therapeutics.

Key References

  1. Lau J, et al. (2015). "Discovery of the once-weekly GLP-1 receptor agonist semaglutide." J Med Chem. 58(18):7370-7380. PMID: 26308095

  2. Marso SP, et al. (2016). "Semaglutide and cardiovascular outcomes." N Engl J Med. 375(19):1834-1844. PMID: 27633186

  3. Wilding JPH, et al. (2021). "Once-weekly semaglutide in adults with overweight or obesity." N Engl J Med. 384(11):989-1002. PMID: 33567185