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Research Context
SLU-PP-332 is a synthetic small molecule developed at Saint Louis University (SLU) by Thomas Bhurley's laboratory. It functions as an agonist of the estrogen-related receptors alpha and gamma (ERRα/ERRγ), which are orphan nuclear receptors involved in mitochondrial biogenesis and oxidative metabolism.
This compound is of significant research interest because ERRs regulate the expression of genes involved in fatty acid oxidation, the TCA cycle, and oxidative phosphorylation — making them central to metabolic research. SLU-PP-332 provides researchers with a pharmacological tool to activate these receptors and study downstream metabolic effects in cellular and animal models.
The compound was first published in 2023 (Weering et al., J Med Chem) and has generated substantial research interest as a tool compound for studying the connection between nuclear receptor signaling and mitochondrial function.
Key References
Weering HR, et al. (2023). "A small molecule agonist of estrogen-related receptor γ." J Med Chem. 66(10):6883-6899.
Narkar VA, et al. (2011). "Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ." Cell Metab. 13(3):283-293. PMID: 21356518
Rangwala SM, et al. (2010). "Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity." J Biol Chem. 285(29):22619-22629. PMID: 20418374