Research Context
Tesamorelin is a synthetic analog of human GHRH(1-44) with a trans-3-hexenoic acid modification at the N-terminus, developed by Theratechnologies. It is one of the few peptides in the research catalog that has received FDA approval (under the brand name Egrifta, 2010) for a specific indication, providing researchers with the advantage of extensive published human pharmacokinetic and safety data.
The compound is valuable as a reference standard for GHRH receptor pharmacology, comparative peptide modification studies, and as a well-characterized control compound for HPLC and mass spectrometry method validation.
Key References
Falutz J, et al. (2007). "Metabolic effects of a growth hormone-releasing factor in patients with HIV." N Engl J Med. 357(23):2359-2370. PMID: 18057338
Stanley TL, et al. (2014). "Effects of tesamorelin on inflammatory and cardiovascular biomarkers." JAIDS. 66(1):39-45. PMID: 24457631